Withdrawal signs and symptoms (such as stress and anxiety, sweating, sleeping disorders, nausea or vomiting, looseness of the bowels, pain, piloerection [bristling of hairs] When tramadol has actually been quickly stopped following dosing for extended durations of time, have actually been reported. The dosage of tramadol ought to constantly be lessened slowly on discontinuation. Tramadol might be made use of for the therapy of moderate-to-severe discomfort such as that triggered by cancer, osteoarthritis, and various other bone and joint conditions.