Withdrawal signs and symptoms (such as stress and anxiety, sweating, sleep problems, nausea or vomiting, diarrhea, pain, piloerection [bristling of hairs] have been reported when tramadol has been suddenly quit following dosing for extensive time periods. The dose of tramadol ought to always be tapered off gradually on discontinuation. Tramadol may be utilized for the therapy of moderate-to-severe pain such as that triggered by cancer cells, osteoarthritis, and various other bone and joint conditions.