Withdrawal symptoms (such as anxiety, sweating, insomnia, queasiness, looseness of the bowels, discomfort, piloerection [bristling of hairs] have been reported when tramadol has been quickly quit following dosing for extended amount of times. The dose of tramadol need to always be tapered off gradually on discontinuation. Tramadol might be utilized for the treatment of moderate-to-severe discomfort such as that triggered by cancer, osteo arthritis, and other bone and joint illness.