Withdrawal signs (such as anxiousness, sweating, sleep problems, nausea, diarrhea, pain, piloerection [bristling of hairs] have actually been reported when tramadol has been suddenly stopped following dosing for extensive amount of times. The dosage of tramadol need to always be reduced gradually on discontinuation. Tramadol may be used for the therapy of moderate-to-severe discomfort such as that caused by cancer, osteoarthritis, and other bone and joint diseases.