Withdrawal symptoms (such as anxiousness, sweating, insomnia, nausea, looseness of the bowels, discomfort, piloerection [bristling of hairs] When tramadol has been abruptly quit adhering to dosing for prolonged periods of time, have actually been reported. The dosage of tramadol ought to constantly be reduced gradually on discontinuation. Tramadol may be used for the therapy of moderate-to-severe discomfort such as that triggered by cancer, osteoarthritis, as well as other bone and joint diseases.