A lot of the physical adjustments brought on by clinical depression, such as sleeping disorders or a lack of deep sleep, are believed to weaken your immune system. Consequently, physical adjustments caused either by clinical depression or persistent condition can cause or worsen depression. All these changes can result in a vicious cycle that is difficult to damage without therapy for both anxiety and any various other conditions. Clinical depression raises your risk of a number of conditions and also other conditions by, for example, enhancing degrees of anxiety hormones such as cortisol or adrenaline.