In the 1990s, Dr. Jack E. Henningfield of the National Institute on Substance Abuse as well as Dr. Neal L. Benowitz of the College of California at San Francisco each rated the 6 most habit forming medications. Mistreating this course of medicines can bring about serious health issue, consisting of dependency and also overdose. Signs of barbiturate overdose consist of clammy skin, expanded pupils, shallow breathing and coma.