In the 1990s, Dr. Jack E. Henningfield of the National Institute on Substance Abuse and also Dr. Neal L. Benowitz of the College of The Golden State at San Francisco each ranked the six most addictive medications. Mistreating this course of drugs can result in severe health issue, consisting of dependency and also overdose. Indications of barbiturate overdose consist of clammy skin, expanded students, superficial breathing as well as coma.