Bis-hydrazides 13a-h were designed and synthesized as potential tubulin inhibitors selectively targeting the colchicine site between α- and β-tubulin subunits. The newly designed ring-B substituents were assisted at their ends by 'anchor groups' which are expected to exert binding interaction(s) with new additional amino acid residues in the colchicine site (beyond those amino acids previously reported to interact with reference inhibitors as CA-4 and colchicine). Conformational flexibility of bis-hydrazide linker assisted these 'extra-binding' properties through reliving ligands' strains in the final ligand-receptor complexes. Compound 13f displayed the most promising computational and biological study results in the series MM/GBSA binding energy of -62.362 kcal/mol (extra-binding to Arg α221, Thr β353 & Lys β254); 34% NCI-H522 cells' death (at 10 µM), IC50 = 0.073 µM (MTT assay); significant cell cycle arrest at G2/M phase; 11.6% preG1 apoptosis induction and 83.1% in vitro tubulin inhibition (at concentration = IC50). Future researchers in bis-hydrazide tubulin inhibitors are advised to consider the 2-chloro-N-(4-substituted-phenyl)acetamide derivatives as compound 13f due to extra-binding properties of their ring B. Fludioxonil has been proven valuable as a broad-spectrum fungicide. However, there are concerns about its risk posed to non-target organisms in aquatic environments. In this paper, the mechanism, photoproducts transformation and eco-toxicity of fludioxonil during •OH/1O2-initiated process were systematically studied using quantum chemistry and computational toxicology. The results indicate that the two favorable pathways of •OH/1O2-initiated reactions are both occurred in pyrrole ring. It can conclude that the rate constants of •OH and 1O2 are 1.23 × 1010 and 3.69 × 107 M-1 s-1 at 298K, respectively, which results in half-lives of less then 2 days in surface waters under sunlit near-surface conditions. Based on toxicity assessments, these photoproducts showed a decreased aquatic toxicity but the majority products are still toxic. This study gives more insight into the chemical transformation mechanism of fludioxonil in aquatic environments. A new Electrocoagulation (EC) technique, sinusoidal AC coagulation (SACC), is creatively put forward for Cu2+ removal in the wastewater from the printed circuit board (PCB) production in this paper. The removal efficiency of Cu2+ from PCB wastewater and energy consumption are compared by SACC and conventional direct current coagulation (DCC). The optimal process parameters were established through analysis of response surface methodology (RSM). The coagulations containing Cu2+ was characterized by SEM, EDS, TEM，BET, XRD and FTIR. The nano-ferrum collosol, mainly composed of goethite (α-FeOOH) and magnetite (γ-Fe2O3), absorbs the Cu2+ and coagulates to remove Cu2+. The results show that the removal rates of Cu2+ by SACC and DCC are 99.86％ and 98.21％, respectively, and the energy consumption is 2.76 × 10-2 kWh⋅m-3 for SACC and 4.42 × 10-2 kWh⋅m-3 for DCC under the optimal process conditions of c0 (Cu2+) = 41.99 mg⋅dm-3, pH = 7.14, j = 0.293 A⋅m-2, t = 16.7 min. The pilot tests indicate that the SACC technique is feasible in industrial application. Cu2+ removal were completed through electrodeposition of Cu2+ on iron electrode, the deposition of Cu(OH)2 and the adsorption of Cu2+ by ferrum collosol. The adsorption follows the pseudo-second order kinetics model well. The maximum saturated adsorption capacity (qmax) of Cu2+ on ferrum collosol produced by SACC is larger than that by DCC. The adsorption of Cu2+ on the ferrum collosol prepared by SACC and DCC are in accordance with Langmuir's adsorption isotherms. The novel SACC technique is a promising technique for the highly-efficient treatment of Cu2+ from PCB wastewater. The respiratory deposition rates are the important analytical parameters for human health risk assessment related to the environmental volatile organic compounds (VOCs). In present study, the deposition rates from the linear regressions of CH2O, CH5N, C2H6O, C2H4O2, C3H8O, C6H6, C7H8, C8H8, and C8H10 of 120 healthy volunteers were obtained with significantly different from the respective calculated deposition rates. The CH2O (formaldehyde) has the highest deposition rate, indicating the highest associated exposure risk of CH2O if the persons are exposed to the same concentrations of these VOCs through inhalation. In order to explore the effects of the breathing models and sampling time on the deposition rates of VOCs, volunteers were first asked to breathe successively with nasal-in-nasal-out, oral-in-nasal-out, and oral-in-oral-out breathing models before and after three meals for three days. Sampling time variation has no effect on the deposition rates of selected VOCs, while the deposition rates of C2H4O2,es of environmental VOCs for health-risk assessment. The persistence and bioaccumulation of environmental pollutants in water bodies, soils and living tissues remain alarmingly related to environmental protection and ecosystem restoration. Adsorption-based techniques appear highly competent in sequestering several environmental pollutants. In this review, the recent research findings reported on the assessments of composts and compost-amended soils as adsorbents of heavy metal ions, dye molecules and xenobiotics have been appraised. This review demonstrates clearly the high adsorption capacities of composts for umpteen environmental pollutants at the lab-scale. The main inferences from this review are that utilization of composts for the removal of heavy metal ions, dye molecules and xenobiotics from aqueous environments and soils is particularly worthwhile and efficient at the laboratory scale, and the adsorption behaviors and effectiveness of compost-type adsorbents for agrochemicals (e.g. Inflammation inhibitor herbicides and insecticides) vary considerably because of variabilities in structure, topology, bond connectivity, distribution of functional groups and interactions of xenobiotics with the active humic substances in composts. Compost-based field-scale remediation of environmental pollutants is still sparse and arguably much challenging to implement if, furthermore, real-world soil and water contamination issues are to be addressed effectively. Hence, significant research and process development efforts should be promptly geared and intensified in this direction by extrapolating the lab-scale findings in a cost-effective manner.